Volume :
2
Issue :
1
Abstract :
Oxidative stress has been suggested to play a key role in the pathogenesis of Diabetic mellitus. Vitamins E and C play important roles in the antioxidant defense system. The purpose of this study was to evaluate the effects of Vitamins E and C (VEC) on diabetic rat in prevention of Streptozotocin induced Type-1 diabetes. Adult albino rats were used in the study, the animals were divided into four groups (n = 6). Group-A: Control group; Group-B: Diabetic group with Streptozotocin (60 mg/kg); Group-C: VEC treatment for seven days followed by Streptozotocin administration and Group-D: Animals treated with Streptozotocin (60 mg/kg), The rats developed diabetes and are evidenced by sustained hyperglycemia and glycosuria after seven days, and then it was treated with VEC for seven days. The observation was made the analysis of blood glucose level and histological architecture of the pancreatic-islet cells. Fasting blood glucose was measured seven days after diabetic induction to determine the severity of blood glucose elevation. Microscopical analysis using Hematoxylin and Eosin (H&E) stain (magnificaionX40) of the VEC administered rats revealed remarkable normal pancreatic-islet cells, unlike the diabetic rats whose Pancreatic-islet cells were necrotic and little in number. VEC effects on serum glucose level was significantly different compared to diabetic control (5.53±0.40 vs. 18.64±3.92 mmol/L, p