Volume :
1
Issue :
4
Abstract :
Herb-drug interaction about Oral antidiabetic drugs is a challenging concept, since the consumption of food and other herbal drugs is not documented in diabetic patients profile. Present work was designed with an objective to investigate any possible effect of herbal drug Piper cubeba Linn. fruits on Pioglitazone-Oral antidiabetic drug. Albino male wistar Rats were made diabetic using Alloxan monohydrate 180 mg/ kg and divided into 4 groups of 6 animals each.Group II, Group-III and Group-IV were administered with Ethanolic extract of Piper cubeba Linn. fruits, EtPCLF (400 mg/kg), Pioglitazone and EtPCLF +Pioglitazone 10mg/kg respectively. All the 4 groups were tested with intraperitoneal glucose tolerance test (IPGTT) by administering glucose (2.5%) intraperitoneally and decrease in blood glucose concentration was determined in each group using glucometer. EtPCLF enhanced the activity of Pioglitazone and significantly lowered Blood glucose concentration in EtPCLF + Pioglitazone treated group when compared to Pioglitazone alone treated group. Hence EtPCLF enhances the activity of Pioglitazone.