Volume :
1
Issue :
4
Abstract :
Tablets of Metoprolol succinate were prepared by direct compression method using Excipients such as HPMC K4M, HPMC K15M, HPMC K100M (rate controlling polymers for extended release, tablet binder), Ethyl cellulose (tablet filler and binder), Colloidal anhydrous silica as tablet disintegrant, microcrystalline cellulose as superdisintegrant, Sodium stearyl fumerate, is used as lubricant. So before selection of all these excipients as well as direct compression method, the Preformulation study of drug Metoprolol succinate is completed for successful formulation of tablet. The % compressibility was calculated of this drug which is required in the selection of direct compression method and was found 13.94% which suits for this direct compression method. The stability of drug was studied in distilled water, Phosphate Buffer 6.8 and as well as in 0.1N HCl which was required for drug analysis to check release profile without degradation of drug in these solvent and found as such no degradation of drug in water, Phosphate Buffer 6.8 as well as in the 0.1N HCl. The drug -excipient compatibility study is carried by simple physical mixing as well as by Infrared Spectroscopy (IR), and as such no major interaction was found between Metoprolol succinate and all selected excipients (HPMC K4M, HPMC K15M, HPMC K100M, Ethyl cellulose, Colloidal anhydrous silica, microcrystalline cellulose, Sodium stearyl fumerate). The drug release from tablet was studied by UV Spectrophometer so interference of additives during analysis was also checked and as such no interference was found by any excipient in the spectral analysis as well as estimation of drug. The solubility of Metoprolol succinate was also calculated and found 95896µg/ml respectively.