Volume :
1
Issue :
4
Abstract :
Quinazolines are found to possess broad spectrum of pharmacological responses. Cancer can be described as the uncontrolled growth of cells and is thought to be caused by the interaction of genetic susceptibility and environmental toxins. Chemotherapy is the most widely used method in the treatment of cancer. The newly synthesized Quinazoline compounds can be screened for their action virtually by the aid of docking softwares such as AutoDock version 1.4 of MGL tools. We performed docking studies for nearly ten derivatives of quinazolines and found that compounds 1e and 1g possess more potent anti-cancer activity than the remaining compounds. This concludes that docking can be employed not only for designing a drug molecule but also to identify its pharmacological activity.