Volume :
1
Issue :
3
Abstract :
Oral route of administration have wide acceptance up to 50-60% to total drug forms. Fast disintegrating drug delivery system has number of advantage such as faster onset of action, attractive elegance, ease of administration, manufacturing, storage and transport. In this study, an attempt has been made to formulate fast disintegrating tablets of Aceclofenac, an analgesic and anti-inflammatory drug in view of enhancing bioavailability in the management of osteoarthritis, rheumatoid arthritis and ankylosing spondilytis. The tablets were formulated by preparing an inclusion complex with Beta Cyclodextrin and molecular dispersion with Polyethylene glycol 6000. The precompression parameters were characterized for flow properties and prepared formulations were evaluated for physico-chemical parameters, in vivo, bioequivalence and pharmacokinetic studies. All four formulations possessed good disintegration properties with total disintegration time of 60 to 240 seconds. The effects of different polymers Beta Cyclodextrin, Polyethylene glycol 6000 and process variables on drug release profile and disintegration property were evaluated and results revealed the better drug release with 2.5% of Polyethylene glycol 6000. Hence, it is evident from this study that fast dispersible tablets could be a promising delivery system for Aceclofenac delivery with good mouth feel and improved drug availability with better patient compliance.