Volume :

1

Issue :

3

Abstract :

Isoniazid condensed with different derivatives of acetophenone to form hydrazones, using Vilsmeier-Haack reagent to form free aldehyde. The free aldehyde reacts with different free amide (R-NH2) group to form imines(C=N) which on react with Chloro acetyl chloride and Triethylamine to gives Azetidin-2-one derivatives. The structures of the newly synthesized compounds have been established on the basis of their spectral data and elemental analysis. Selected compound were evaluated for antibacterial activity.