Volume :
1
Issue :
2
Abstract :
A precise and feasible high-performance liquid chromatographic (HPLC) method for the analysis of the novel antipsychotic drug quetiapine in tablet dosage form has been developed. The analysis was carried out on a Phenomix Stainless Steel C18 (250 x 4.6 mm, 5 μ) reversed-phase column, using a mixture of phosphate buffer (pH 3), acetonitrile, methanol (50:40:10) as the mobile phase using a low pressure gradient mode with flow rate at 0.8ml/min. The injection volume was 20µl..The retention time of the drug was 4.69 min. The method produced linear responses in the concentration range of 1 to 5μg/ml of Quetiapine fumerate. The LOD and LOQ values for HPLC method were found to be 0.0167 and 0.0506 μg/ml respectively. The method was found to be applicable for determination of the drug in tablets.