Volume :
1
Issue :
2
Abstract :
The present study was undertaken with an aim to formulation development and evaluation of gastroretentive floating tablets of venlafaxine hydrochloride, which releases the drug in a sustained manner over a period of 12 hours. Three different viscosity grades of Hydroxypropylmethylcellulose (HPMC) namely K4M, K15M, and K100M were used for the preparation of tablets. The tablets were prepared by direct compression and evaluated for tablet thickness, weight variation, tablet hardness, friability, in vitro buoyancy test, in vitro drug release and Fourier transform infrared (FT-IR) spectroscopy. Formulation F3 can be considered as an ideal or optimized formulation for gastroretentive floating tablet of venlafaxine HCl. The optimized formulation showed sufficiently sustained drug release and remained buoyant on the surface of the medium for more than 12 hours. As the concentration of HPMC increases in the formulation the drug release rate was found to be decreased. It can be concluded that floating drug delivery system of venlafaxine HCl can be successfully formulated as an approach to increase gastric residence time and there by improving its bioavailability.