Volume :
1
Issue :
1
Abstract :
The aim of present study was to prepare and characterize sustained release glipizide matrix tablet using synthetic (Sodium alginate, carbopol) and natural (chitosan, xanthan gum) polymers as a cost effective, nontoxic, easily available, hydrophilic matrix system when compared with extensively investigated hydrophilic matrices [sodium alginate], [carbopol]. Matrix tablets of Glipizide (dose 10mg) were prepared by wet granulation method at different ratios of 1:5,1:6,1:7,1:8 (Drug: polymers) . Release kinetics was studied using United states of Pharmacopeia (USP)-22 type I dissolution apparatus. Further more in vitro and in vivo datas of newly formulated sustained-release Glipizide tablets were compared with conventional marketed tablet (Glipizide,India). The in vitro release study revealed that formulation containing chitosan showed sustained release of 96.4% up to 12 h. Sustained release formulation of Glipizide containing chitosan showed good bioavailability and pharmacokinetic profile from the in vivo study carried out on rat. Thus the results suggest the developed sustained-release tablets of Glipizide performed therapeutically better than conventional dosage forms, leading to improved bioavailability, therapeutic efficacy with better patient compliance.