Abstract :
Introduction: Olanzapine, a widely used atypical antipsychotic agent is known to cause nephrotoxic effects after
prolonged use. Aim of the study was to find out detailed histopathological and histomorphometric information
which might throw light on the mechanism of toxicity of olanzapine.
Material & Methods: Twelve albino rats were divided into equal number of experimental and control groups i.e. 6
each. Experimental rats received olanzapine, 4mg/kg, intraperitoneally for 6 weeks. Kidney tissue was processed
for H/E stain.
Observation & Results: Extensive degenerative changes with generalized edema was observed as
histopathological findings. Histomorphometry showed shrinkage of Bowman’s capsule and glomeruli.
Conclusion: Degeneration of kidney due to prolonged use of olanzapine is confirmed which might be due to
direct effect on the organ or indirect effect due to toxicities on other organs.
Keyword :
Olanzapine, kidney, albino rats.