Volume :
6
Issue :
2
Abstract :
The present study was aimed to evaluate the hepatoprotective effect of Jasminum Sambac flower extract (JSFE) in acute experimental liver injury induced by Carbon tetrachloride (CCl4), alcohol, paracetamol (PCM) and thioacetamide (TAA) in rats. In Ccl4, alcohol, PCM and TAA models rats were treated with 10, 15, 5 and 7 days respectively. To induce the liver toxicity 24 hour after the last treatment CCl4(2ml/kg. s.c), PCM (2g/kg, p.o.) and TAA (100mg/kg, s.c.) was administered where as for alcohol model alcohol (30% 1.5ml,p.o. twice a day) was given for 15 days. Rats were received different treatments such as silymarin (100 mg/kg), low and high doses of Jasminum Sambac flower extract (JSFE 100 and 500 mg/kg,) orally. The protective effect of prophylactic treatment was analysed by estimation of serum biomarkers like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and bilirubin (total and direct) and by histopathological observation. The activities of serum biomarkers were significantly decreased in all treated groups compared with toxic control. It was concluded that high and the low dose of Jasminum Sambac flower extract (JSFE) demonstrated reduced serum biomarkers activity significantly which was supported by histopathological study.