Volume :
5
Issue :
1
Abstract :
Aim
To study the role of allopurinol as an oxygen free radical scavenger, in prevention of myocardial ischemic reperfusion injury in albino rabbits.
Materials and Methods
An experimental analytical study was carried out after getting approval from institutional animal ethical committee. Albino Rabbits of either sex were divided into two groups control (n=5) and test group (n=5), receiving antioxidant allopurinol. Experiments were done using isolated heart perfusion apparatus (Langendorff apparatus). The experiment was divided into three phases perfusion (15 min) followed by ischemia (5 min) followed by reperfusion (15 min). LDH level of perfusate and coronary flow were taken as biochemical and physiological marker of myocardial reperfusion injury respectively were measured at 5, 10 and 15 min of post ischemic period. Control and test groups were compared.
Result
The result shows that in the group receiving allopurinol the decrease in post ischemic LDH level was significant (p