Abstract :
C-reactive protein (CRP) was first discovered in 1930 by William Tillet and Thomas Francis. CRP plays a role in the innate immune system by activating the complement pathway. Through the calcium dependent binding of ligands containing phosphocholine, as well to the phospholipids of damaged cells, CRP enhances the uptake of damaged cells by macrophages. Initially, CRP was considered a pathogenic secretion elevated in people suffering from one of many forms of tissue damage. However, and synthesis by hepatocytes demonstrates that CRP is a native protein. At the transcriptional level, CRP is regulated by the cytokine interleukin (IL)-6 and enhanced IL-1, with tumour necrosis factor (TNF)-? possibly playing a part in CRP synthesis through influencing IL- 6 production.
Keyword :
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