Abstract :
As inflammation had a role in every stage of atherogenesis and
hypertension, in turn leading to Cardiovascular Disease. Hs-CRP level
estimation can be an important screening method for assessing the risk.
Thus, this study to evaluate the effect of essential hypertension on hsCRP levels in Indian adult population. As well as clustering of other
cardiovascular risk factors in comparison with a control group in a
population.
Acase-control study was carried out in of Era's Lucknow Medical
College & Hospital, Lucknow, and Uttar Pradesh. All patients coming
in out-patient department were screened for inclusion & exclusion
criteria. Those selected were subjected to screening of risk factors of cardiovascular diseases & serum hs CRP
estimation.Significant CAD risk factors in our cases came out to be: higher weight (p-value: 0.0470), raised BMI
(>25) (p-value: 0.005), higher waist circumference (p-value: 0.0010) & smoking (p-value: 0.008). Average hs-CRP
values in the hypertensive group (cases) was higher (2.85 ± 2.4 mg/L) than in normotensive group (control) (2.36 ±
2.08 mg/L). No significant difference in values among the controlled & uncontrolled group of previously diagnosed
hypertensives was observed but a significant difference was found between newly diagnosed Stage I & Stage II
hypertensives.Also, though not significant a rising trend was noted in hs-CRP values with an increase in the risk
category. On CAD risk stratification according to hs CRPvalues cases hada significantly higher prevalence of hs-CRP
levels than controls. Conclusion: The study did not reveal any significant difference in hs CRPvalues in hypertensives
than from the normotensive population. But the significant difference between Stage I & Stage II of hypertension was
observed in hs-CRPvalues.
Keyword :
C - reactive protein, Cardiovascular , Atherogenesis, Hypertension.