Volume :

4

Issue :

4

Abstract :

Recent developments in Oro-dispersible/disintegrating tablets have brought convenience in dosing to elderly and children who have trouble in swallowing tablets. The objective of the present study was to prepare the mouth disintegrating tablet of ivabradine. Tablets of drug were prepared by sublimation method or technique. In the formulation of ivabradine oro dispersible tablets, initially ivabradine fused with cross Carmellose sodium (optimized super disintegrate), is used as API and sublimating agent menthol were added to the formulation, results showed that 99% was released in 15min in formulation (F7), and 94% was released in 30min from the formulation containing super disintegrant Cross povidone (F8), and 95% was released in 30min from the formulation containing super disintegrant sodium starch glycolate (F9). In formulation F7, the super disintegrant CCS (15%) and sublimating agent menthol (10%) was added and 99% was released in 15min, which is the highest amongst all and hence this is finalized. All these tablets showed required hardness, limited friability and good disintegration time (with in IP and USP limits). All the formulations were evaluated for drug content and results are obtained. Amongst all formulations, formulation F7 and CCS as super disintegrant showed the least disintegration time and faster dissolution.