Abstract :
For the drug designing for ovarian cancer, finding the inhibitor of PI3 Kinase protein catalytic subunit
p110α having interaction with the protein, p110α was docked with a list of inhibitors known to interact with it.
After retrieving the sequence and the structure of protein, it was docked with its inhibitors and the inhibitor with
best docking results provides best interaction with the PI3 Kinase protein catalytic subunit p110α.
As is evident from AutoDock docking programme in this study, ZSTK474 proves to be the best inhibitor among
the others to inhibit PI3 Kinase protein catalytic subunit p110α because it has low docked energy which signifies
better interaction of ligand with the protein. The present article provides general information regarding the ovarian
cancer and also includes various existing information collected from various databases.
Keyword :
Ovarian cancer, PI3 kinase, p110α, Computer aided drug designing