Objectives: The study was conducted to assess the frequency of incidence of ADRs in our hospital, its causality with the suspected drug, severity of the ADR, preventability of ADRs and its relation to the duration of stay.
Method: A prospective study was conducted in a tertiary care hospital in Bangalore for a period of 12 months. Standard procedure was followed in reporting the ADRs by all healthcare personnel. Naranjo and Hartwig scales were used to assess the causality and severity of ADRs reported. Further analysis was made to evaluate the preventability and effect of duration of hospitalization on occurrence of ADRs.
Results: A total of 160 ADRs were reported during the study period from various specialties. Males comprised of 102(63.75%) and females were 58(36.25%). The assessment by Naranjo scale showed that relationship of ADR and the suspected drug was definite in 12 cases, probable in 45 cases, possible in 88 cases and doubtful in 15 cases. Hartwig scale classified 84 cases to be mild, 44 to be of moderate in severity and 20 to be severe. Preventability assessment was made that showed that 44 cases of ADR were definitely preventable, 12 probably preventable and 104 ADRs not preventable. Length of stay in the hospital showed a positive correlation with the occurrence of ADRs.
Conclusion: Adverse drug reactions are a significant health issue in India due to noncompliance and advent of polypharmacy. But majority of the ADRs can be avoided by the knowledge and awareness among all health care professionals. Standardized training of health professionals and reporting of ADRs not only helps in the prevention of ADRs in the hospitals, but also reduces the number of admissions related to ADRs.
Adverse drug reactions, Causality, Severity, Preventability