Abstract :
Aim: Diabetes mellitus is specifically a condition of hyperglycemia, insulin resistance, and relative impairment in insulin secretion.It is characterized by micro and macro vascular complications that lead to significant morbidity and mortality. Diabetic peripheral neuropathy is one of the most common long term complications of DM. HbA1c estimation is usually done which is indicative of glycaemic control. Nerve conduction studies (NCS) are electrodiagnostic tests used to evaluate the ability of the electrical conduction of the motor and the sensory nerves.
Therefore the effect of HbA1c on the nerve conduction velocity in Type 2 Diabetes Mellitus Patients was studied.
Methodology: Total number of 60 subjects (diabetic subjects and the healthy controls) were examined to assess the Diabetic neuropathy. Sensory Nerve conduction velocity (NCV) test was done along with the estimation of HbA1c levels in all the diabetic subjects (HbA1c?6.5%) and the healthy controls.
Results: The analysis showed that the nerve conduction velocity decreased in diabetic patients with apoor glycaemic control in comparison to healthy and diabetic subjects with good glycaemic control.
Conclusion: In diabetic subjects there is progressive neuronal involvement which is accelerated by poor glycaemic control leading to development of diabetic neuropathy. Therefore, NCS can be employed for the early detection of neuropathy in diabetic patients.
Keyword :
Diabetes mellitus, Nerve conduction studies, Glycated haemoglobin