Indian Journal of Pharmacy and Pharmacology


Online-Issn No :
2393-9087
Print-Issn No :
2393-9079
Language :
English
Publisher :
IP Innovative Publication Pvt. Ltd.

Indexed - 2016 : IPI Value (4.1)

Indexed - 2017 : IPI Value (3.22)

Indexed - 2018 : IPI Value (3.46)

Indexed - 2019 : IPI Value (3.50)


The motor coordination activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by rota rod test


Article PDF :

Veiw Full Text PDF

Article type :

Research Article

Author :

Devesh D Gosavi, Amit S Kamdi, Suvarna M Kalambe, Pankaj N Bohra

Volume :

7

Issue :

2

Abstract :

Background: The central nervous system (CNS) depressant effect is caused by the numerous sedative and hypnotic drugs that are currently used. Though in the late seventies some work was done on Withania coagulans, it is the vulnerable species not widely scattered. Therefore, it was worthy to investigate the CNS depressant activities of alcoholic extract of Withania coagulans fruits in Swiss albino mice by using rota rod test. Aim: To study the motor coordination activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by Rota Rod Test. Materials and Methods: Motor coordination was measured by using the Rota Rod Test. The CNS depressant drugs reduce the endurance time of mice on the rotating rod as they weaken the motor coordination so that mice fall early on the revolving rod. This endurance time is tested statistically among the control, standard and the test drugs. Statistical Analysis: One way ANOVA was used for the statistical analysis. Results: The endurance time in Swiss albino mice was statistically highly significantly (p-value < 0> associated with the alcoholic extract of Withania coagulans fruits on rota rod test. Conclusion: The alcoholic extract of Withania coagulans fruits established the CNS depressant activity in Swiss albino mice by rota rod test.

Keyword :

 CNS depressant, Rota rod test, Swiss albino mice (SAM), Withania coagulans.

Doi :

10.18231/j.ijpp.2020.015

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