Background: The central nervous system (CNS) depressant effect is caused by the numerous sedative and
hypnotic drugs that are currently used. Though in the late seventies some work was done on Withania
coagulans, it is the vulnerable species not widely scattered. Therefore, it was worthy to investigate the CNS
depressant activities of alcoholic extract of Withania coagulans fruits in Swiss albino mice by using rota
Aim: To study the motor coordination activity of alcoholic extract of Withania coagulans fruits in Swiss
albino mice by Rota Rod Test.
Materials and Methods: Motor coordination was measured by using the Rota Rod Test. The CNS
depressant drugs reduce the endurance time of mice on the rotating rod as they weaken the motor
coordination so that mice fall early on the revolving rod. This endurance time is tested statistically among
the control, standard and the test drugs.
Statistical Analysis: One way ANOVA was used for the statistical analysis.
Results: The endurance time in Swiss albino mice was statistically highly significantly (p-value < 0> associated with the alcoholic extract of Withania coagulans fruits on rota rod test.
Conclusion: The alcoholic extract of Withania coagulans fruits established the CNS depressant activity in
Swiss albino mice by rota rod test.
CNS depressant, Rota rod test, Swiss albino mice (SAM), Withania coagulans.