Abstract :
A number of physiologic cutaneous changes occurs during pregnancy due to immunologic, hormonal
or metabolic factors. Pathologic skin lesions are rare but its important to distinguish due to potentially
detrimental effects on both mother & fetus. Pemphigoid gestationis is a rare pruritic autoimmune
dermatosis associated with several adverse fetal outcomes. 30yrs old primigravida at 22weeks gestation
presented to us with an intensely pruritic vesicobullous lesion which was further diagnosed as pemphigoid
gestationis. Hence patient was started on Prednisone & Azathioprine, then gradually tapered to appropriate
maintainance dose. Patient had preterm rupture of membranes and delivered a healthy baby vaginally.
Proper management of this dermatological condition requires a suitable drug therapy, close monitoring
and multi disciplinary team approach which is essential to reduce maternal and neonatal morbidity and to
achieve favourable obstetric outcome.
Keyword :
Pemphigoid gestationis, Autoimmune dermatosis, Vesicobullous lesion, Prednisone, Azathioprine