Abstract :
Background: Thyroid hormones & TSH are associated with the etiology of type 2 diabetes (T2DM) and
probably contribute to the development of the various complications of T2DM. The association of thyroid
hormones & TSH with cardiovascular diseases in confirmed hypothyroid patients is still not clear.
Aim & Objectives: The aim of our study is to determine the correlation of HbA1c with thyrotropin
(TSH) and thyroid hormones in the development of cardiovascular diseases (CVD) in known patients of
hypothyroidism.
Materials and Methods: This was a case control observational study carried out among total of 172
patients (100 patients and 72 controls). They were divided into in to two groups cases which are hypothyroid
patient and control group. Blood sample (3 ml) was collected and Fasting blood sugar, complete lipid profile
were assayed on Vitros 250 auto analyzer Johnson and Johnson USA.
The circulating thyroid hormones assayed for T3, T4 and TSH by enzyme linked florescent assay (ELFA)
technique using Vidas auto-analyzer.
Glycosylated hemoglobin measured by kit based method where anticoagulated whole blood used as sample.
Body weight and height were measured for body mass index (BMI) (kg/m2).
Results: Our study demonstrate that Mean of BMI, W.C, FBS, HbA1c, TC, TG, LDL and VLDL were
higher in cases as compared to HDL which is higher in control group as compared to case group,
Our study also shows that serum T3 values correlates positively and significantly with waist circumference
and triglyceride also, while T4 correlates positively and significantly with waist circumference, fasting
sugar level, triglycerides and LDL-C while correlates only positively with, HbA1c and HDL-C, whereas
TSH correlates positively only with LDL and HDL Levels.
Conclusion: Our study concludes that the cumulative quantification of indicators like TSH & HbA1c
will function as a biomarker for hypothyroid patients who are at risk to develop CVD in their later stages
of life.
Keyword :
Glycosylated hemoglobin, Hypothyroid, TSH, CVD.