Abstract :
In the present work efforts have been made to develop immediate release tablets of
Metoprolol succinate using direct compression technique involving super disintegrants like
croscaremallose sodium, sodium starch glycolate. The pre compression parameters like
angle ofrepose , bulk density, true density, compressibility index are within the IP limit. The
post compression parameters are acceptable and within the IP limit. In-vitro drug release at
for all the formulations was found to be 95 to 99% and was satisfactory. The optimized
formulation F6 (10% sodium starch glycolate) of drug release was found to be is 99% at 30
min.
Keyword :
Immediate release, Super Disintegrants and bioavailability