Abstract :
In the present work efforts have been made to develop fast dissolving tablets of Metoprolol succinate using
direct compression technique involving super disintegrants like cross povidone, sodium starch glycolate. The
pre compression parameters like angle of repose, bulk density, true density, compressibility index are within the
IP limit. The post compression parameters are acceptable and within the IP limit. In-vitro drug release at for
all the formulations was found to be 95 to 99% and was satisfactory. The optimized formulation
(F6,10%cross povidone) of drug release was found to be is 99% at 30 min.
Keyword :
fast dissolving tablets, Mouth Dissolving Drug Delivery System and Metoprolol succinate