Abstract :
OBJECTIVE: To determine the clinical profile of patient with thrombocytopenia at tertiary care hospital.
PATIENTS AND METHODS: This descriptive case series study for one year was conducted at tertiary care
hospital Hyderabad on the patients who had clinical manifestation due to thrombocytopenia. The inclusion
criteria of the study were patients, of ≥12 years of age, either gender, had thrombocytopenia counts less than 1,
50,000/µl with or without clinical manifestations. The investigations relevant to detect etiology were advised
while the severity of thrombocytopenia was categorized as mild, moderate and severe. The data was collected
on pre-designed proforma and analyzed in SPSS 16. The frequency and percentage was calculated while mean
± SD was computed for numerical variables.
RESULTS: During one year study period total one hundred patients of thrombocytopenia were recruited and
studied. Majority of the patients belonged to rural population (78%). The mean ±SD for age and platelet count
was 38.98 ±8.95 years and 1, 10500 ± 4500 / µl respectively while the mortality was detected as 11%. The male
population was predominant 53%, the fever is the most common clinical presentation observed in all participant
while the other common symptoms observed were gum bleeding (19%), hematuria (19%), menorrhagia (15%)
and melena (14%). The common etiological factors detected as Plasmodium vivax (21%), Plasmodium
falciparum (16%), dengue (19%), tuberculosis (13%) and viremia (13%) while the bleeding time was detected
as prolonged in 37% respectively.
CONCLUSION: The thrombocytopenia is a common and life threatening complication of febrile illness
especially of infectious origin.
Keyword :
Platelet, Thrombocytopenia, Megakaryocytes