Abstract :
Background: Thyroid disorders are established risk factor for insulin resistance. In this study we find out whether
association exists between insulin resistance in type 2 diabetes patients with and without nephropathy and thyroid
disorders. Methods: Serum T3 T4 TSH, fasting and postprandial blood sugar, HbA1c, serum insulin levels, serum
creatinine, and urinary albumin creatinine ratio were estimated in 100 patients with type 2 DM. These patients were divided
into two groups of 50 patients, Group 1 – type 2 DM without nephropathy and Group 2 - type 2 DM with nephropathy.
Results: In our study we found a statistically significant correlation between TSH and serum insulin levels in patients with
diabetic and diabetic nephropathy. Out of 100 patients thyroid dysfunction was more prevalent in diabetic nephropathy
group as compared to diabetic without nephropathy group. P-value for thyroid dysfunction in diabetic nephropathy was
statistically significant. In present study higher prevalence of thyroid dysfunction in women as compared to men.
Conclusion: Routine assessment of thyroid hormone level in addition to other biochemical parameters in the early stage of
diabetes and diabetes nephropathy will help in the management of those patients whose condition are difficult to manage.
Keyword :
Thyroid function Tests (T3 T4 TSH). Type 2 Diabetes Mellitus, Insulin Levels.