Abstract :
A sensitive, precise, accurate, simple and rapid spectrophotometric method has been developed for the estimation of Teneligliptin in pharmaceutical formulations and in the drug dosage form. During the course of study, it is observed that acidic solution of the drug formed the oxidation product with Bromate Bromide mixture. This property of the drug is exploited for the development of spectrophotometric method for the determination and analysis of the drug. The oxidation product showed max at 250 nm. The linearity range for Teneligliptin is found to be 10 µg ml to 250 µg ml. Recovery studies gave satisfactory results indicating that none of common additives and excipients interfere the assay method. The molar absorptivity and the sandell sensitivity of the method are evaluated and the values are found to be to be 1.1645×104 lit mole cm and 0.0366 µg ml cm2 respectively. I. Lakshmi Prasanna | G. T. Naidu | G. Abdul Huq "Spectrophotometric Oxidation Method for the Determination of Teneligliptin by Using Bromate Bromide Mixture" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-5 , August 2018, URL: https://www.ijtsrd.com/papers/ijtsrd18253.pdf Paper URL: http://www.ijtsrd.com/physics/other/18253/spectrophotometric-oxidation-method-for-the-determination-of-teneligliptin-by-using-bromate---bromide-mixture/i-lakshmi-prasanna
Keyword :
Spectrophotometry, Teneligliptin, Bromate-Bromide oxidant, Pharmaceutical formulations