Abstract :
Background & Objective: Chronic Kidney Disease (CKD) is emerging as an important
public health problem across the world. In severe cases, the disease progresses
towards end stage renal disease (ESRD) which is associated with several complications.
In recent years, 25 (OH) Vitamin D has been identified as a risk factor for ESRD. Vitamin
D plays a vital role in regulating parathyroid hormone (PTH) synthesis and release.
Decreased Vitamin D levels are identified as a risk factor for secondary
hyperparathyroidism (SHPT) which is one of the major complications of CKD and is
associated with renal osteodystrophy. The present study was planned to assess the
status of 25 (OH) Vitamin D and its role in secondary hyperparathyroidism in patients
with CKD. Materials and Methods: The study was conducted on 50 diagnosed cases of
CKD (stage 4 and 5), age < 60 years. Age and sex matched healthy subjects (n = 50)
constituted the control group. Serum 25(OH) Vitamin D and iPTH were estimated for
all the enrolled subjects. BMI and eGFR were also calculated. All variables were
compared among the control and diseased group. Results: Vitamin D levels were
significantly low in the CKD group as compared to the control group (p
Keyword :
Chronic Kidney Disease, Vitamin D, Parathyroid hormone, Secondary Hyperparathyroidism, End Stage Renal Disease