Abstract :
Medicinal plants have been an important part in the healthcare management using traditional medicine. They have contributed to the generation of novel drugs and in the treatment of various diseases. Cellular damage caused by reactive oxygen species (ROS) has been implicated in several diseases. Cancer is a major public health burden in both developed and developing countries. Anticancer activity is the effect of natural and synthetic or biological and chemical agents to reverse, suppress or prevent carcinogenic progression. Several synthetic agents are used to cure the disease but they have their toxicity and hence the research is going on to investigate the plant derived chemotherapeutic agents. Natural antioxidants have significant importance in human health. Calotropis gigantea, a medicinal plant has been reported to possess different therapeutic properties. In the present study, in vitro antioxidant status and anti carcinogenic properties of C. gigantea were analysed using most commonly accepted assays that is reducing power assay and DPPH assay. The in vitro cytotoxic activity of C. gigantea extract using the MTT assay against MCF-7 and PC-3 cell lines.
By Jim Thomas | M. Suresh Kumar | T. Selvan Kumar"In vitro anti-oxidant and anti-carcinogenic properties of Calotropis gigantea (L.) R. Br. in its methanolic stem extracts"
Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-1 | Issue-6 , October 2017,
URL: http://www.ijtsrd.com/papers/ijtsrd4587.pdf
Paper URL: http://www.ijtsrd.com/biological-science/biotechnology/4587/in-vitro-anti-oxidant-and-anti-carcinogenic-properties-of--calotropis-gigantea-l-r-br-in-its-methanolic-stem-extracts/jim-thomas
Keyword :
Calotropis gigantea, in vitro antioxidant activity, in vitro cytotoxic activity, cell lines, MTT assay