Objectives: To assess the anxiolytic activity of ROUSVASTATIN in male albino mice. To compare the anxiolytic activity of ROUSVASTATIN with standard drug as diazepam.
Materials and Methods: The study was conducted in Pharmacology Dept., JJM medical college. Rousvastatin and Diazepam were dissolved in saline. Control group mice were injected with saline. Drugs and saline were injected intraperitoneally.
Results: In elevated plus maze Rousvastatin at dose 30 mg/kg and 50mg/kg increased number of open arm and total arm entries, time spent in open arm and decreased time spent in closed arm.
Conclusion: The results suggest that the significant dose-dependent antianxiety activity of Rousvastatin is similar to the behavioural effects of Diazepam.
Anxiolytic activity, Rousvastatin, Diazepam