Indian Journal of Clinical and Experimental Ophthalmology


Online-Issn No :
2395-1451
Print-Issn No :
2395-1443
Language :
English
Publisher :
IP Innovative Publication Pvt. Ltd.

Indexed - 2016 : IPI Value (3.9)

Indexed - 2017 : IPI Value (4.02)

Indexed - 2018 : IPI Value (3.7)

Indexed - 2019 : IPI Value (3.44)


Clinical study to evaluate safety and efficacy of tacrolimus 0.1% eye ointment in treatment of vernal keratoconjunctivitis


Article PDF :

Veiw Full Text PDF

Article type :

Original Article

Author :

Rajni Sethia, R N Kothari, Vivan Desai, Aditya Desai, Anjasi Patel.

Volume :

3

Issue :

4

Abstract :

Introduction: Vernal keratoconjunctivitis is a seasonally recurring, chronic, allergic bilateral inflammatory disorder of the conjunctiva and cornea caused due to immune mediated hypersensitivity reaction. Tacrolimus is an immunomodulator which induces suppression of T lymphocytes activity and causes reduction of ocular inflammation. Hence, in our present study we aim to evaluate the efficacy of 0.1% tacrolimus eye ointment as first line therapy in the management of Vernal Keratoconjunctivitis. Materials and Methods: This was a clinical, prospective and interventional study including 100 eyes of 50 patients with VKC which were serially selected. 0.1% tacrolimus eye ointment was instilled twice daily over a period of 12 weeks. On every fortnightly follow up, patients were assessed for 5 symptoms and 4 signs and the severity was graded as 0 (normal), 1+ (mild), 2+ (moderate), or 3+ (severe)in order to evaluate the efficacy of the drug. Results: There were 50 patients with VKC comprising of 41 males and 09 females. After treatment with Tacrolimus 0.1% eye ointment, there was statistically significant improvement in symptoms of VKC including itching, redness, photosensitivity, foreign body sensation and mucus discharge (P

Keyword :

Allergy, Immunosupressant, Inflammatory, Tacrolimus, Vernal keratoconjunctivitis.

Doi :

10.18231/2395-1451.2017.0108

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