Abstract :
Diabetes mellitus is a multi-factorial disorder related to a dysregulated metabolism. a holistic technique emphasizing each of the person factors with regards to finish pathophysiology of the disease is vital to our information of this heterogeneous disorder. numerous technical advances inside the area of purposeful genomics which include metabolomics and proteomics useful resource in comprehending the nation of the overall organic machine and for this reason can be applied to decipher the complicated interactions among additives of the metabolic machine in human diabetes. above-referred to strategies combined with a fixed of bioinformatics equipment and available databases goal to profile big selection of proteins and metabolites repertoire in humans. the accurate and comprehensive measurements of those molecules is hired to analyze complicated interactions of metabolites and proteins now not simplest amongst themselves but additionally with genes, transcripts and other small molecules to decipher cell microenvironment and the results due to drug intervention. this assessment gives an overview of the applications of metabolomics in human diabetes studies. we additionally talk the ability of combining exceptional bioinformatics tools with the omics technique to improve the medical expertise closer to discovery of biomarkers to monitor and adjust general human fitness with appreciate to the deregulated metabolic state, a function of diabetes mellitus.
by Seema Ahad"Clinical Applications of Metabolomics in Diabetes Research"
Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-2 , February 2018,
URL: http://www.ijtsrd.com/papers/ijtsrd8360.pdf
Paper URL: http://www.ijtsrd.com/biological-science/biochemistry/8360/clinical-applications-of-metabolomics-in-diabetes-research/seema-ahad
Keyword :
Diabetes; Metabolomics; Gas chromatography; Liquid chromatography; Non-magnetic resonance