A Study of Histopathological Spectrum of Non Neoplastic Urothelial Lesions


Article PDF :

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Article type :

Original article

Author :

Dr. Nisha Attri

Volume :

11

Issue :

6

Abstract :

Background: Specimens from the bladder are commonly encountered by the general surgical pathologist. Emphasis is usually placed on the neoplasms of bladder, particularly if malignant, owing to their bad prognosis. A good command of benign lesions occurring in the bladder, and knowledge of their preneoplastic potential will help pathologists to confidently diagnose malignancy versus its benign mimickers and guide the urologists in choosing the appropriate therapy for the patient. Aims & Objectives: To present a mixture of benign entities, and discuss their histologic characteristics, hoping to provide a practical review for the general surgical pathologist. To discuss group of benign disorders that can cause diffuse bladder wall thickening and might be misdiagnosed as malignancy on cystoscopy. Material and Methods: A retrospective study of 10 years was carried out on bladder biopsies received from Jan 2004 to Dec 2014 at a tertiary care hospital in mumbai. The histopathological records of patients were screened for collection of data like age, sex, clinical history, gross and microscopy. The final diagnosis was given on routine Hematoxylin & Eosin stained sections. Results: Total 123 cases of non neoplastic bladder lesions were studied, out of which 69 were males and 54 were females with male to female ratio being 1.3:1.The spectrum of non neoplastic pathological lesions included cystitis, nephrogenic adenoma, BCG induced granuloma, malakoplakia and endometriosis. Cystitis was the most common finding. Most common age group affected by the non neoplastic lesions was 41-50 years of age. Conclusion: A wide variety of benign entities are present in the bladder and are more commonly encountered by the general surgical pathologist. Knowledge of the histologic characteristics of these lesions, their preneoplastic potential, and the possible pitfalls can help the pathologist serve the patient better.

Keyword :

Bladder, Benign, Cystitis, Histopathological spectrum, Non neoplastic
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