Abstract :
Background: Glaucoma is an ischemic optic neuropathy comprising of raised intraocular pressure, optic disc changes and
visual field defects. Due to fear of loss of vision, the therapy of Primary Open Angle Glaucoma (POAG) targets lowering the
IOP by either medical or surgical means. The aim of the study is to compare the reducing efficacy of IOP using
Dorzolamide and Latanoprost topical eye drops in patients with Primary open angle glaucoma. Methods: The study was
conducted in the Department of Ophthalmology, Teerthankar Mahaveer Medical College, TMU, Moradabad. Sixty patients
were recruited for the study and divided into two groups of 30 each. Group D were administered with Dorzolamide 2% eye
drops thrice daily while Group L received Latanoprost 0.005%eye drops once daily. Results: Out of all sixty patients,
56.67% belong to 41-60 years of age group. 28.33% of the patients were of more than 61 years of age and only 9 patients
i.e. 15% were of between 20-40 year of age. The mean baseline IOP in Group D was 26.60 ± 2.91 mmHg and in Group L
was 26.82 ± 2.23 mmHg (P=0.22). The mean IOP gradually decreases until 12th week in both the groups and the results
were comparable in between the groups. The percent change in IOP in Group D was 29.97% and in Group L was 38.82%.
Conclusion: Although both (latanoprost and dorzolamide) drugs were well tolerated by all the patients but the efficacy in
decreasing IOP is superior with latanoprost.
Keyword :
Dorzolamide, Glaucoma, Latanoprost.